In August 2007, Simone Dinnerstein released her debut solo CD on Telarc, a recording of the Goldberg Variations which earned the No. 1 spot on the Billboard Classical Chart during its first week of sales. The disc appeared on "Best of 2007" lists including those of The New York Times, The Los Angeles Times, The New Yorker, Time Out New York, several radio stations, iTunes "Editor's Choice Best Classical," Amazon.com Best CDs of 2007, and Barnes & Noble's Top 5 Debut CDs of 2007. In September 2008, the recording received the prestigious Diapason d'Or Award in France.
The New York Times reported, "An utterly distinctive voice in the forest of Bach interpretation, Ms. Dinnerstein brings her own pianistic expressivity to the Goldberg Variations, probing each variation as if it were something completely new." Slate.com raved, "Dinnerstein is a throwback to such high priestesses of music as Wanda Landowska and Myra Hess . . . [She] is touring. Go hear her, and get religion. And if you can't, there's always the record." In October 2007, Ms. Dinnerstein gave her sold-out debut recital at London's Wigmore Hall performing the Goldberg Variations, after which The Guardian proclaimed, "In Dinnerstein's accomplished hands, there was no doubt that [Bach's Goldberg Variations] are the province of the true musician rather than the mere pianist."