Subsequently Joan Jeanrenaud moved to Geneva, Switzerland to study with Pierre Fournier. At age 22, Jeanrenaud joined the Kronos Quartet and relocated to San Francisco. For twenty years she worked with hundreds of composers and musicians such as John Cage, Terry Riley, Morton Feldman , Philip Glass, Joan Armatrading, David Byrne, John Zorn and many others. The quartet performed more than 2,000 concerts in the most renowned venues in the world and made more than 30 recordings, most of which were released on Nonesuch Records.
She left the Kronos Quartet in 1999 to pursue independent artistic directions including composition, improvisation, electronics, video and multi-disciplinary performance. Jeanrenaud was an Artist-In-Residence at San Francisco's Yerba Buena Center for the Arts in the 2000/2001 season where she developed an evening length solo multi-media work, "Metamorphosis" (which received its world premiere at the Walker Art Center, May, 2001), and "Ice Cello," a four hour installation piece inspired by the work of Fluxus artist Charlotte Moorman.